Catalytic hotspots get noisy

Get Happy, Get Rich

The world’s poor, whether they live in dangerous urban slums or in the remote countryside, are often in dire need of food, clean water, and basic medications. So it might appear misguided to argue that mental health should be a primary rather than secondary concern in developing countries. But the reality is that mental health is not just a First World problem: disorders such as depression are ...

Get Syk and get cycling

Overenthusiastic repair of damaged blood vessels could cause a fatal blockage. Sedding et al. (page 2801) report that the normal repair-restricting function of factor VII activating protease (FSAP) is disrupted by a common mutation. People carrying the mutation might thus be more at risk of vessel narrowing. Approximately 5% of the population carries an FSAP polymorphism linked to cardiovascula...

Warfare in biodiversity hotspots.

Conservation efforts are only as sustainable as the social and political context within which they take place. The weakening or collapse of sociopolitical frameworks during wartime can lead to habitat destruction and the erosion of conservation policies, but in some cases, may also confer ecological benefits through altered settlement patterns and reduced resource exploitation. Over 90% of the ...

SequenceLDhot: detecting recombination hotspots

MOTIVATION There is much local variation in recombination rates across the human genome--with the majority of recombination occurring in recombination hotspots--short regions of around approximately 2 kb in length that have much higher recombination rates than neighbouring regions. Knowledge of this local variation is important, e.g. in the design and analysis of association studies for disease...

Biodiversity Hotspots in India